Bioss Inc.'s MARK2 (1F10) Monoclonal Antibody is a Rabbit monoclonal antibody. The MARK2 (1F10) Monoclonal Antibody was generated using MARK2 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule.stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein